The .22 Hornet or 5.6×35mmR is a varminting, small-game hunting, survival and competition centerfire rifle cartridge commercially introduced in 1930. It is considerably more powerful than the rimfire .22 WMR and the .17 HMR, achieving higher velocity with a bullet twice the weight of the .17 HMR bullet. The Hornet also differs very significantly from these in that being a centerfire cartridge makes it reloadable, and thus much more versatile. It was the smallest commercially available .22 caliber centerfire cartridge until the introduction of the FN 5.7×28mm.
The .22 Hornet fills the gap between such popular varmint/predator cartridges as the .22 WMR and the .223 Remington. In regard to muzzle velocity, muzzle energy and noise, it is well suited to vermin and predator control in relatively built-up areas.